Control of immediate early splicing through core components of the spliceosome (A15)

• Subject Area: Biochemistry
• Term: since 2016
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 278001972

Project A15 investigates transcriptome-wide switches in cellular splicing programs, in particular immediate early splicing switches that depend on transient phosphorylation of splicing factors and core components of the spliceosome, implemented via signaling cascades. RNA sequencing, RNA-protein interaction studies, proteomics, minigene assays and structural analysis are used to explore the molecular mechanisms, functionality and cell type specificity of immediate early splicing switches. The project also develops tools to modulate spliceosome-associated molecular switches for the further investigation of splicing switches.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 186: Molecular Switches: Spatio-temporal Control of Cellular Signal Transmission
• Applicant Institution: Freie Universität Berlin
• Project Heads: Professor Dr. Florian Heyd; Professor Dr. Markus C. Wahl