Dynamics of complex membrane assemblies probed by native mass spectrometry (P24*)

• Subject Area: Biochemistry
• Term: from 2016 to 2020
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 57566863

Crucial processes within cells depend on specific non-covalent interactions, which mediate the assembly of proteins and other biomolecules. We employ mass spectrometry and ion-mobility measurements to monitor protein stoichiometries, binding of ligands, lipid, and nucleotides as well as conformational changes and how these are interrelated. We will as well develop a method to investigate binding strength of membrane protein complexes in a quantitative way.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 807: Transport and Communication across Biological Membrans
• Applicant Institution: Goethe-Universität Frankfurt am Main
• Project Head: Professorin Dr. Nina Morgner, since 7/2016