Lysinacylierung in zellulärer Regulation, Alterung und Krankheit

• Antragsteller: Professor Dr. Michael Lammers
• Fachliche Zuordnung: Biochemie
• Förderung: Förderung von 2016 bis 2018
• Projektkennung: Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 318191341

• Erstellungsjahr: 2018

Zusammenfassung der Projektergebnisse

Keine Zusammenfassung vorhanden

Projektbezogene Publikationen (Auswahl)

• Insights into K-Ras 4B regulation by post-translational lysine acetylation. Biological Chemistry, Bd. 397. 2016, Heft 10, S. 1071-1085.
  Knyphausen P., Lang F., Baldus L., Extra A., Lammers M.
  
• Insights into Lysine Deacetylation of Natively Folded Substrate Proteins by Sirtuins. Journal of Biological Chemistry, Vol. 291. 2016, pp. 14677-14694.
  Knyphausen P., de Boor S., Kuhlmann N., Scislowski L., Extra A., Baldus L., Schacherl M., Baumann U., Neundorf I., Lammers M.
  
• Novel Coronin7 interactions with Cdc42 and N-WASP regulate actin organization and Golgi morphology. Scientific Reports, Vol. 6. 2016, Article number: 25411.
  Bhattacharya K., Swaminathan K., Peche V.S., Clemen C.S., Knyphausen P., Lammers M., Noegel A.A., Rastetter R.H.
  
• A KRAS GTPase K104Q Mutant Retains Downstream Signaling by Offsetting Defects in Regulation. Journal of Biological Chemistry, Vol. 292. 2017, pp. 4446-4456.
  Yin G., Kistler S., George S.D., Kuhlmann N., Garvey L., Huynh M., Bagni R.K., Lammers M., Der C.J., Campbell S.L
  
• Development of Substrate-Derived Sirtuin Inhibitors with Potential Anticancer Activity. ChemMedChem, Vol. 12. 2017, Issue 20, pp. 1703-1714.
  Kuhlmann N., Chollet C., Baldus L., Neundorf I., Lammers M.
  
• DNA repair network analysis reveals shieldin as a key regulator of NHEJ and PARP inhibitor Sensitivity. Cell, Vol. 173. 2018, Issue 4, pp. 972-988. e23.
  Gupta R., Somyajit K., Narita T., Maskey E., Stanlie A., Kremer M., Typas D., Lammers M., Mailand N., Nussenzweig A., Lukas J., Choudhary C.
  
• Expression and Purification of Site-Specifically Lysine-Acetylated and Natively-Folded Proteins for Biophysical Investigations. In: Edward A. Lemke (Ed.), Noncanonical Amino Acids. Methods in Molecular Biology, Vol. 1728. 2018, pp. 169-190.
  Lammers M.