Targeting BCL2 protein family in mitochondrial diseases (B06)

• Subject Area: Cell Biology
• Term: since 2016
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 269925409

Our previous studies using a mouse model for mitochondrial hepatopathy identified mitochondrial apoptosis as an important surveillance mechanism that counteracts the manifestation of the mitochondrial disease in liver. Here, we aim to investigate the (patho-)physiological role of apoptosis in mitochondrial diseases caused by mtDNA mutation in mice. This project will explore the role of apoptosis in different tissues affected by mitochondrial dysfunction.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1218: Mitochondrial regulation of cellular function
• Applicant Institution: Universität zu Köln
• Project Head: Professor Dr. Hamid Kashkar