Ubiquitin-dependent coordination of mitochondrial-cytoplasmic quality control (B03)

• Subject Area: Cell Biology
• Term: since 2016
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 269925409

Ubiquitin-dependent degradation of outer mitochondrial membrane (OMM) proteins has been implicated in the dynamic regulation of mitochondrial-cytosolic communication, but little is known about its mechanistic regulation and physiological consequences. To monitor OMM protein turnover in a multicellular organism, we developed a fluorescent reporter assay in C. elegans based on an OMM-anchored GFP-tagged reporter substrate. The main goal of the proposed research is to understand how physiological and metabolic changes regulate ubiquitin-dependent OMM protein degradation in an organismal context.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1218: Mitochondrial regulation of cellular function
• Applicant Institution: Universität zu Köln
• Project Head: Professor Dr. Thorsten Hoppe