Mitochondrial Hydrogen Peroxide Signalling (B02)

• Subject Area: Biochemistry
• Term: since 2016
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 269925409

Mitochondria are among the major generators of cellular H2O2. The release of mitochondrial H2O2 has been proposed to drive various signaling processes to align mitochondrial functions with the remainder of the cell. In this project, we aim to understand how mitochondria handle and release H2O2, and how they use the molecule to communicate. Specifically, we will develop new genetic tools to modulate and monitor small redox molecules with subcellular resolution. With these tools, we will follow the dynamics and crosstalk of these redox molecules upon specific spatially confined perturbations. We also performed and will perform CRISPR screens to identify novel players in mitochondrial H2O2 handling and release, and characterize them in molecular detail.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1218: Mitochondrial regulation of cellular function
• Applicant Institution: Universität zu Köln
• Project Head: Professor Dr. Jan Riemer