The role of mitochondrial dynamics in mtDNA maintenance (A06)

• Subject Area: Cell Biology
• Term: from 2016 to 2019
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 269925409

Fundamental principles for the organisation, distribution and maintenance of mtDNA in mammalian cells are poorly understood, despite the huge impact of altered mtDNA expression on mitochondrial and age-associated diseases. We will investigate how impaired mitochondrial outer membrane fusion affects nucleoid distribution and mtDNA mutation complementation. Furthermore, we will define nucleoid protein components in mouse tissues in vivo in conditions with altered mtDNA expression.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1218: Mitochondrial regulation of cellular function
• Applicant Institution: Universität zu Köln
• Co-Applicant Institution: Max-Planck-Institut für Biologie des Alterns
• Project Head: Professor Dr. Nils-Göran Larsson