Biobank of human right ventricular tissue, lung and blood specimens from CTEPH patients (CP01)

• Subject Area: Cardiology, Angiology
• Term: since 2016
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 268555672

RNA sequencing of RV samples of chronic thromboembolic pulmonary hypertension (CTEPH) pre (n=100) and post (n=34) pulmonary thrombendarterectomy (PEA) revealed specific gene expression patterns. Morphometric data proved RV reverse remodeling after PEA. Now transcriptomic and proteomic results will be correlated with clinical data. The data provided to the different CRC1213 projects will, e. g. be analyzed for functional relevance as potential biomarkers for PH, and the topography of regulated genes will be assessed and related to function. The biobank will be broadened by 1) collecting PA wall samples during PEA, 2) RV biopsies from patients with chronic thromboembolic pulmonary disease (CTEPD) as control, and 3) right atrial biopsies.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1213: Pulmonary Hypertension and Cor Pulmonale
• Applicant Institution: Justus-Liebig-Universität Gießen
• Project Heads: Dr. Peter Dorfmüller; Professor Dr. Christoph Liebetrau, until 6/2024; Professor Dr. Eckhard Mayer, until 6/2024; Privatdozent Dr. Christoph Wiedenroth; Dr. Athiththan Yogeswaran