Allostery and Proteostasis of Regulated Actomyosin Systems in Human Cardiomyocytes

• Applicant: Professor Dr. Dietmar J. Manstein
• Subject Area: Biochemistry ; Cardiology, Angiology ; Structural Biology
• Term: from 2016 to 2020
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 314376469

• Final Report Year: 2021

Final Report Abstract

No abstract available

Publications

• (2018) Co-polymers of Actin and Tropomyosin Account for a Major Fraction of the Human Actin Cytoskeleton. Curr. Biol. 28, 2331-2337 e2335
  Meiring, J. C. M., Bryce, N. S., Wang, Y., Taft, M. H., Manstein, D. J., Liu Lau, S., Stear, J., Hardeman, E. C., and Gunning, P. W.
  (See online at https://doi.org/10.1016/j.cub.2018.05.053)
• (2017) Tropomyosin Isoforms Specify Functionally Distinct Actin Filament Populations in vitro. Curr. Biol. 27, 705-713
  Gateva, G., Kremneva, E., Reindl, T., Kotila, T., Kogan, K., Gressin, L., Gunning, P. W., Manstein, D. J., Michelot, A., and Lappalainen, P.
  (See online at https://doi.org/10.1016/j.cub.2017.01.018)
• (2018) Variants in exons 5 and 6 of ACTB cause syndromic thrombocytopenia. Nat. Commun. 9, 4250
  Latham, S. L., Ehmke, N., Reinke, P. Y. A., Taft, M. H., Eicke, D., Reindl, T., Stenzel, W., Lyons, M. J., Friez, M. J., Lee, J. A., Hecker, R., Fruhwald, M. C., Becker, K., Neuhann, T. M., Horn, D., Schrock, E., Niehaus, I., Sarnow, K., Grutzmann, K., Gawehn, L., Klink, B., Rump, A., Chaponnier, C., Figueiredo, C., Knofler, R., Manstein, D. J., and Di Donato, N.
  (See online at https://doi.org/10.1038/s41467-018-06713-0)
• (2019) Phenamacril is a reversible and noncompetitive inhibitor of Fusarium class I myosin. J. Biol. Chem. 294, 1328-1337
  Wollenberg, R. D., Taft, M. H., Giese, S., Thiel, C., Balazs, Z., Giese, H., Manstein, D.J. , and Sondergaard, T. E.
  (See online at https://doi.org/10.1074/jbc.RA118.005408)
• (2020) Actintropomyosin distribution in non-muscle cells. J. Muscle Res. Cell Motil. 41, 11-22
  Manstein, D. J., Meiring, J. C. M., Hardeman, E. C., and Gunning, P. W.
  (See online at https://doi.org/10.1007/s10974-019-09514-0)
• (2020) Enhanced super-resolution microscopy by combined Airyscan and Quantum-Dot-Triexciton Imaging
  Hennig, S., and Manstein, D. J.
  (See online at https://doi.org/10.1101/2020.05.07.082222)
• (2020) Mechanochemical properties of human myosin 1C are modulated by isoform-specific differences in the N-terminal extension. J Biol Chem
  Giese, S., Reindl, T., Reinke, P. Y. A., Zattelman, L., Fedorov, R., Henn, A., Taft, M. H., and Manstein, D. J.
  (See online at https://doi.org/10.1074/jbc.RA120.015187)
• (2020) Myosin-18B Regulates Higher-Order Organization of the Cardiac Sarcomere through Thin Filament Cross-Linking and Thick Filament Dynamics. Cell Rep. 32, 108090
  Latham, S. L., Weiss, N., Schwanke, K., Thiel, C., Croucher, D. R., Zweigerdt, R., Manstein, D. J., and Taft, M. H.
  (See online at https://doi.org/10.1016/j.celrep.2020.108090)
• (2020) Small Molecule Effectors of Myosin Function. Adv Exp Med Biol 1239, 61-84
  Manstein, D. J., and Preller, M.
  (See online at https://doi.org/10.1007/978-3-030-38062-5_5)
• (2020) Undefeated-Changing the phenamacril scaffold is not enough to beat resistant Fusarium. PLoS One 15, e0235568
  Wollenberg, R. D., Donau, S. S., Taft, M. H., Balazs, Z., Giese, S., Thiel, C., Sorensen, J. L., Nielsen, T. T., Giese, H., Manstein, D. J., Wimmer, R., and Sondergaard, T. E.
  (See online at https://doi.org/10.1371/journal.pone.0235568)
• (2021) Muscle myosin performance measured with a synthetic nanomachine reveals a class-specific Ca2+-sensitivity of the frog myosin II isoform. J Physiol.
  Pertici, I., Bianchi, G., Bongini, L., Cojoc, D., Taft, M.H., Manstein, D.J., Lombardi, V., Bianco, P.
  (See online at https://doi.org/10.1113/JP280976)