The role of the Alzheimer related Amyloid Precursor Protein Gene Family in the Developing and Adult Nervous System

Applicant Professorin Dr. Ulrike Müller

Subject Area Molecular Biology and Physiology of Neurons and Glial Cells

Term from 2006 to 2010

Project identifier Deutsche Forschungsgemeinschaft (DFG) - Project number 30636411

Final Report Year 2010

Final Report Abstract

No abstract available

(2008) Activity requires soluble amyloid precursor protein alpha to promote neurite outgrowth in neural stem cell-derived neurons via activation of the MAPK pathway. Eur J Neurosci 28: 871-882
Gakhar-Koppole N, Hundeshagen P, Mandl C, Weyer SW, Allinquant B, Müller U, Ciccolini F
(2008) Embryonic stem cell-derived neurons as a cellular system to study gene function: lack of amyloid precursor proteins APP and APLP2 leads to defective synaptic transmission. Stem Cells 26: 2153-2163
Schrenk-Siemens K, Perez-Alcala S, Richter J, Lacroix E, Rahuel J, Korte M, Müller U, Barde YA, Bibel M
(2010) Generation of conditional null alleles for APP and APLP2. Genesis 48: 200-206
Mallm JP, Tschape JA, Hick M, Filippov MA, Müller UC
(2010) Neurons generated from APP/APLP1/APLP2 triple knockout embryonic stem cells behave normally in vitro and in vivo: lack of evidence for a cell autonomous role of the amyloid precursor protein in neuronal differentiation. Stem Cells 28: 399-406
Bergmans BA, Shariati SA, Habets RL, Verstreken P, Schoonjans L, Müller U, Dotti CG, De Strooper B