KFO 167:  Apoptoseregulation und ihre Störungen bei Krankheiten

• Fachliche Zuordnung: Medizin
• Förderung: Förderung von 2006 bis 2013
• Projektkennung: Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 29548890

• Erstellungsjahr: 2015

Zusammenfassung der Projektergebnisse

Keine Zusammenfassung vorhanden

Projektbezogene Publikationen (Auswahl)

• Telomerase deletion limits progression of p53-mutant hepatocellular carcinoma with short telomeres in chronic liver disease. Gastroenterology, Vol. 132. 2007, Issue 4, pp. 1465-1475.
  Lechel A., Holstege H., Begus Y., Schienke A., Kamino K., Lehmann U., Kubicka S., Schirmacher P., Jonkers J., Rudolph K.L.
  (Siehe online unter https://doi.org/10.1053/j.gastro.2007.01.045)
• Thirty-eight-negative kinase 1 (TNK1) facilitates TNFalpha-induced apoptosis by blocking NF-kappaB activation. Oncogene, Vol. 26. 2007, pp. 6536–6545.
  Azoitei N., Brey A., Busch T., Fulda S., Adler G., Seufferlein T.
  (Siehe online unter https://doi.org/10.1038/sj.onc.1210476)
• DNA-ligase IV and DNA-protein kinase play a critical role in deficient caspases activation in apoptosis-resistant cancer cells by using doxorubicin. Molecular Biology of the Cell, Vol. 19. 2008, No. 8, pp. 3179-3613.
  Friesen C., Uhl M., Pannicke U., Schwarz K., Miltner E., Debatin K.M.
  (Siehe online unter https://doi.org/10.1091/mbc.e08-03-0306)
• Resveratrol modulates DNA double-strand break repair pathways in an ATM/ATR-p53- and -Nbs1-dependent manner. Carcinogenesis, Vol. 29. 2008, Issue 3, pp. 519–527.
  Gatz S.A., Keimling M., Baumann C., Dörk T., Debatin K.M., Fulda S., Wiesmüller L.
  (Siehe online unter https://doi.org/10.1093/carcin/bgm283)
• Identification of a novel pro-apopotic function of NF-kappaB in the DNA damage response. Journal of Cellular and Molecular Medicine, Vol. 13. 2009, Issue 10, pp. 4239-4256.
  Karl S., Pritschow Y., Volcic M., Häcker S., Baumann B., Wiesmüller L., Debatin K.M., Fulda S.
  (Siehe online unter https://doi.org/10.1111/j.1582-4934.2009.00888.x)
• The inability to disrupt the immunological synapse between infected human T cells and APCs distinguishes HIV-1 from most other primate lentiviruses. Journal of Clinical Investigation, Vol. 119. 2009, Issue 10, pp. 2965–2975.
  Arhel N., Lehmann M., Clauss K., Nienhaus G.U., Piguet V., Kirchhoff F.
  (Siehe online unter https://dx.doi.org/10.1172/JCI38994)
• Refractory chronic lymphocytic leukemia--new therapeutic strategies. Oncotarget, Vol.1. 2010, Issue 7, pp. 472-482.
  Schnaiter A., Stilgenbauer S.
  
• Targeting mitochondria for cancer therapy. Nature Reviews Drug Discovery, Vol. 9. 2010, Issue 6, pp. 447–464.
  Fulda S., Galluzzi L., Kroemer G.
  (Siehe online unter https://doi.org/10.1002/em.20552)
• Diversity of human leukemia xenograft mouse models: implications for disease biology. Cancer Research, Vol. 71. 2011, Issue 23, pp. 7141-7144.
  Meyer L.H., Debatin, K.M.
  (Siehe online unter https://dx.doi.org/10.1158/0008-5472.CAN-11-1732)
• Identification of a novel proapoptotic role of NF-kappaB in the regulation of TRAIL- and CD95-mediated apoptosis of glioblastoma cells. Oncogene, Vol. 31. 2012, Issue 11, pp. 1468–1474.
  Jennewein C., Karl S., Baumann B., Micheau O., Debatin K.M., Fulda S.
  (Siehe online unter https://doi.org/10.1038/onc.2011.333)
• Puma and p21 represent cooperating checkpoints limiting self-renewal and chromosomal instability of somatic stem cells in response to telomere dysfunction. Nature Cell Biology, Vol. 14. 2012, Issue 1, pp. 73–79.
  Sperka T., Song Z., Morita Y., Nalapareddy K., Guachalla L.M., Lechel A., Begus-Nahrmann Y., Burkhalter M.D., Mach M., Schlaudraff F., Liss B., Ju Z., Speicher M.R., Rudolph K.L.
  (Siehe online unter https://doi.org/10.1038/ncb2388)
• Anti-CD33-antibodies labelled with the alpha-emitter Bismuth-213 kill CD33-positive acute myeloid leukaemia cells specifically by activation of caspases and break radio- and chemoresistance by inhibition of the anti-apoptotic proteins X-linked inhibitor of apoptosis protein and B-cell lymphoma-extra large. European Journal of Cancer, Vol. 49. 2013, Issue 11, pp. 2542-2554.
  Friesen C., Roscher M., Hormann I., Leib O., Marx S., Moreno J., Miltner E.
  (Siehe online unter https://dx.doi.org/10.1016/j.ejca.2013.04.008)
• Sustained, neuron-specific IKK/NF-kappaB activation generates a selective neuroinflammatory response promoting local neurodegeneration with aging. Molecular Neurodegeneration, Vol. 8. 2013, Article number: 40.
  Maqbool A., Lattke M., Wirth T., Baumann B.
  (Siehe online unter https://doi.org/10.1186/1750-1326-8-40)
• Fluorescence-based recombination assay for sensitive and specific detection of genotoxic carcinogens in human cells. Archives of Toxicology, Vol. 88. 2014, pp. 1141–1159.
  Ireno I.C., Baumann C., Stöber R., Hengstler J.G., Wiesmüller L.
  (Siehe online unter https://doi.org/10.1007/s00204-014-1229-3)
• Viremic long-term nonprogressive HIV-1 infection is not associated with abnormalities in known Nef functions. Retrovirology, Vol. 11. 2014, Article number: 13.
  Heigele A., Camerini D., van't Wout A.B., Kirchhoff F.
  (Siehe online unter https://doi.org/10.1186/1742-4690-11-13)
• Targeting inhibitor of apoptosis proteins by Smac mimetic elicits cell death in poor prognostic subgroups of chronic lymphocytic leukemia. International Journal of Cancer, Vol. 137. 2015, Issue 12, pp. 2959-2970.
  Opel D., Schnaiter A., Dodier D., Jovanovic M., Gerhardinger A., Idler I., Mertens D., Bullinger L., Stilgenbauer S., Fulda S.
  (Siehe online unter https://doi.org/10.1002/ijc.29650)
• Intrinsic and chemo-sensitizing ctivity of Smac-mimetics on high-risk childhood acute lymphoblastic leukemia. Cell Death & Disease, Vol. 7. 2016, e2052.
  Schirmer M., Trentin L., Qeudeville M., Seyfried F., Eckhoff S.M., Debatin K.M., Meyer L.M.
  (Siehe online unter https://doi.org/10.1038/cddis.2015.382)