Mechanismen der protektiven Wirkung von Darbepoetin bei biliärer Fibrose

• Subject Area: General and Visceral Surgery
• Term: from 2006 to 2015
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 29528568

• Final Report Year: 2009

Final Report Abstract

No abstract available

Publications

• Attenuation of inflammation and apoptosis by pre- and posttreatment of darbepoetin-alpha in acute liver failure of mice. Am J Pathol. 2007;170:1954-63
  Le Minh K, Klemm K, Abshagen K, Eipel C, Menger MD, Vollmar B
  
• Darbepoetin-alpha does not promote microvascular thrombus formation in mice: role of eNOS-dependent protection through platelet and endothelial cell deactivation. Arterioscler Thromb Vasc Biol. 2007;27:1191-8
  Lindenblatt N, Menger MD, Klar E, Vollmar B
  
• Erythropoietin improves functional and histological recovery of traumatized skeletal muscle tissue. J Orthop Res. 2008;26:1618-26
  Rotter R, Menshykova M, Winkler T, Matziolis G, Stratos I, Schoen M, Bittorf T, Mittlmeier T, Vollmar B
  
• Multiple doses of erythropoietin impair liver regeneration by increasing TNF-alpha, the Bax to Bcl-xL ratio and apoptotic cell death. PLoS One. 2008;3:e3924
  Klemm K, Eipel C, Cantré D, Abshagen K, Menger MD, Vollmar B
  
• Effects of erythropoietin in skin wound healing are dose related. FASEB J. 2009;23:3049-58
  Sorg H, Krueger C, Schulz T, Menger MD, Schmitz F, Vollmar B
  
• Erythropoietin reduces necrosis in critically ischemic myocutaneous tissue by protecting nutritive perfusion in a dose-dependent manner. Surgery. 2009;145:372-83
  Harder Y, Amon M, Schramm R, Contaldo C, Metzkow E, Matzen A, Rücker M, Vollmar B, Menger MD