Modeling molecular and cellular mechanisms of clonal evolution in indolent B cell lymphoma (A12)

• Subject Area: Hematology, Oncology
• Term: from 2016 to 2020
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 278529602

Follicular lymphoma (FL), a highly heterogeneous B-cell malignancy, is still incurable in most cases. The project posits that the tumor immune microenvironment imposes profound constraints upon FL evolution and that FL cells in turn corrupt their environment to their advantageous growth, including resistance against therapy. To shed light onto this co-evolution, it will analyse primary patient samples, as well as mouse models by using gene expression profiling, high parameter flow cytometry as well as immunofluorescence imaging, cross-species bioinformatics and CRISPR/Cas9-based validation.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1243: Genetic and Epigenetic Evolution of Hematopoietic Neoplasms
• Applicant Institution: Ludwig-Maximilians-Universität München
• Co-Applicant Institution: Technische Universität München (TUM)
• Project Head: Professor Dr. Marc Schmidt-Supprian