Role of mitochondrial quality control in hepatic encephalopathy (B09)

• Subject Area: Biochemistry
• Term: from 2016 to 2020
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 190586431

Hepatic encephalopathy (HE) is a neuropsychatric syndrome caused by various forms of liver dysfunction. Resulting hyperammonemia leads to modulation of autophagy/ mitophagy and rapid metabolic reprogramming in astrocytes. In this context, we aim to better understand the mechanistic role of mitochondrial quality control, focusing on mitophagy and autophagy, and of energy metabolism for the pathogenesis of HE. For this we will use suitable in vitro-, organoid-, and in vivo-models. Thereby, we hope to find novel strategies for HE treatment.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 974: Communication and System Relevance in Liver Injury and Regeneration
• Applicant Institution: Heinrich-Heine-Universität Düsseldorf
• Project Head: Professor Dr. Andreas Reichert