Project Details
Projekt
Role of platelets in liver injury and regeneration (A16)
Subject Area
Cell Biology
Term
from 2016 to 2020
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 190586431
In this project three aspects should be investigated in experimental mouse models to characterize the role of bile acids for platelet-mediated effects on cellular responses upon liver injury and regeneration. In a first step, we want to understand the role of the bile acid receptor TGR5 in haemostasis and thrombosis. Secondly, we plan to characterize bile acid-induced TGR5 activation at the platelet membrane and the mechanisms and consequences for platelet activation defects after liver injury. Thirdly, we want to determine the impact of platelet TGR5 for platelet-mediated inflammation and cell survival after liver injury. In a first translational approach, we plan to identify the coincidence of liver injury and alterations in platelet signalling in patients with cholestatic liver disease.
DFG Programme
Collaborative Research Centres
Applicant Institution
Heinrich-Heine-Universität Düsseldorf
Project Head
Professorin Dr. Margitta Elvers
