Searching for the engram at the proteome level (B15*)

• Subject Area: Molecular Biology and Physiology of Neurons and Glial Cells
• Term: from 2016 to 2019
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 36555331

In project B15N, we deal with the ¿where¿ and ¿what¿ of long-term memory. Requirement for de novo protein synthesis is a characteristic of long-term memory. The respective proteins should be critical for memory consolidation and long-lasting storage. Notwithstanding their importance, a comprehensive, cell-specific inventory of these proteins so far does not exist. We combine in the fruit fly, a well-established long-term memory paradigm with in vivo, cell-specific metabolic protein labeling. We aim at localizing a long-term associative engram by visualizing de novo protein synthesis; and at characterizing this engram¿s molecular content by identifying the newly synthesized proteins.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 779: Neurobiology of Motivated Behaviour
• Applicant Institution: Otto-von-Guericke-Universität Magdeburg
• Project Heads: Professorin Dr. Daniela C. Dieterich; Dr. Ayse Yarali