Project Details
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MAIRA - Highly efficient and accurate algorithms for mobile analysis of microbes

Subject Area Bioinformatics and Theoretical Biology
Parasitology and Biology of Tropical Infectious Disease Pathogens
Term from 2015 to 2021
Project identifier Deutsche Forschungsgemeinschaft (DFG) - Project number 289436404
 
Final Report Year 2021

Final Report Abstract

The aim of this project was to develop new algorithms and software to support real-time analysis of mobile sequencing technologies. One main result of this work is an improved understanding of the challenges specific to the analysis of metagenomic long reads, such as the problem of frame shifts caused by sequencing errors. This has led to the development of new algorithms to address these challenges and the extension of the DIAMOND+MEGAN metagenomic analysis pipeline so as to accommodate long reads. A second main result is the development of the new MAIRA program, which runs on a laptop and processes the output of a MinION sequencing in real-time. We are currently exploring the use of MAIRA to monitor the dynamics of microbial communities in bioreactors. In future, the software will be extended to applications in genome mining. Moreover, we intend to deploy the software for in-field DNA analysis in situations in which access computational infrastructure is difficult.

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