Function and regulation of systemic and local complement C3 in immune-mediated kidney diseases (B06)

• Subject Area: Pathology
• Term: since 2016
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 264599542

In this project, we will address the hypothesis by determining: 1) Patterns and associated effects of C3 dysregulation in human immune-mediated kidney diseases; 2) Molecular mechanism of C3-induced immune cell milieu alterations in a mouse model of local and systemic conditional C3 KO; and 3) Molecular understanding of complement C3- and complement convertase-dysregulation by Factor H-Related Protein 1. Success of these aims will enhance understanding of the functions and mechanisms of the complement system in immune-mediated kidney diseases.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1192: Immune-Mediated Glomerular Diseases - Basic Concepts and Clinical Implications -
• Applicant Institution: Universität Hamburg
• Project Heads: Dr. Tilo Freiwald; Professor Dr. Thorsten Wiech