The (immuno)proteasome as a modifier of podocyte membrane dynamics in membranous nephrophathy (B03)

• Subject Area: Nephrology
• Term: since 2016
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 264599542

The overall goal of this project is to unravel the functional role of the (immuno)proteasome at footprocesses in MN. We will characterize 1) the mechanisms connecting the proteasome system with podocyte plasma membrane dynamics using Drosophila melanogaster; 2) the pathomechanistic function of immunoproteasomal degradation for footprocess proteostasis and remodeling in experimental mammalian models of MN and 3) the potential of glomerular and urinary MN-associated ectosomes in the prediction of MN severity and outcome. Collectively, our results will demonstrate, if the immunoproteasome-dependent formation of MN-associated ectosomes in podocytes represents a general pathophysiologic concept with therapeutic and prognostic value in membranous nephropathy.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1192: Immune-Mediated Glomerular Diseases - Basic Concepts and Clinical Implications -
• Applicant Institution: Universität Hamburg
• Project Heads: Dr. Sybille Köhler; Professorin Dr. Catherine Meyer-Schwesinger