Autophagy regulates drug response in activated B cell-like diffuse large B cell lymphoma (E06 (C06))

• Subject Area: Hematology, Oncology
• Term: from 2016 to 2023
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 259130777

This project focusses on the role of autophagy in regulating drug responsiveness in aggressive lymphomas. We showed that selective autophagy plays a key role in regulating the efficacy of BTK inhibitors in aggressive lymphomas. Now we will analyze the underlying molecular mechanisms to find ways to therapeutically exploit this pathway. We will elucidate the exact autophagy pathway that influences drug response by a proteogenomic approach, investigate how relevant survival factors are targeted to autophagosomal degradation upon BTK inhibitor treatment, and identify synergistic drug combinations that act through this newly identified cell-toxic autophagy pathway.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1177: Molecular and Functional Characterization of Selective Autophagy
• Applicant Institution: Goethe-Universität Frankfurt am Main
• Project Heads: Professor Dr. Thomas Oellerich; Professor Dr. Hubert Serve, until 12/2019