Function of effector Treg subsets in glomerulonephritis (A03)

• Subject Area: Nephrology
• Term: since 2016
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 264599542

In the current grant application, we aim to address the following aspects in mice and human GN patients: 1.) Define the hitherto unknown role of IKZF3 for generation, stability and function of RORγt+ Tregs and other effector Tregs in GN. 2.) Assess the function of CXCR6 for effector Treg trafficking, homeostasis and expansion in GN. 3.) Unravel the functional heterogeneity and potential plasticity of RORγt+ effector Tregs under inflammatory conditions.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1192: Immune-Mediated Glomerular Diseases - Basic Concepts and Clinical Implications -
• Applicant Institution: Universität Hamburg
• Project Head: Professor Dr. Oliver Michael Steinmetz, since 1/2020