Allosteric regulation of UDP-sugar pyrophosphorylases as a means to develop new anti-parasitic treatments

• Applicant: Dr. Roman Fedorov
• Subject Area: Biochemistry ; Biophysics ; Structural Biology
• Term: from 2015 to 2020
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 282955187

• Final Report Year: 2021

Final Report Abstract

No abstract available

Publications

• Structural and biochemical studies of sulphotransferase 18 from Arabidopsis thaliana explain its substrate specificity and reaction mechanism. (2017) Sci. Rep. 7(1):4160
  Hirschmann F, Krause F, Baruch P, Chizhov I, Mueller JW, Manstein DJ, Papenbrock J, Fedorov R
  (See online at https://doi.org/10.1038/s41598-017-04539-2)
• Decoding Allosteric Networks in Biocatalysts: Rational Approach to Therapies and Biotechnologies. (2018) ACS Catalysis. 8:2683- 2692
  Cramer JT, Baruch P, -J, Gerardy-Schahn R, and Fedorov R
  (See online at https://doi.org/10.1021/acscatal.7b03714)
• Identification of Leishmania major UDP-Sugar Pyrophosphorylase Inhibitors Using Biosensor-Based Small Molecule Fragment Library Screening. (2019) Molecules, 24(5): 996
  Prakash O, Führing J, Post J, Shepherd SM, Eadsforth TC, Gray D, Fedorov R and Routier FH
  (See online at https://doi.org/10.3390/molecules24050996)
• Allosteric modulation of cardiac myosin mechanics and kinetics by the conjugated omega-7,9 trans-fat rumenic acid. (2021) J Physiol 599.15: 3639–3661
  Pertici I, Taft MH, Greve JN, Fedorov R, Marco Caremani M, and Manstein DJ
  (See online at https://doi.org/10.1113/JP281563)