Project Details
Projekt
Synaptic plasticity and stability in the context of hippocampal information processing
Applicant
Professor Dr. Jörn Simon Wiegert
Subject Area
Molecular Biology and Physiology of Neurons and Glial Cells
Term
from 2015 to 2023
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 278170285
We aim at understanding how synaptic activity, function and stability are linked. We will focus on individual, functionally identified Schaffer collateral synapses of the hippocampus. After having investigated the connection between long-term plasticity and synaptic stability in the first funding period, we now want to understand how complete suppression of transmission of a subset of synapses with unaffected neighbors influences their structural dynamics. We will investigate the link between the original strength of synapses and their structural plasticity. We will further measure spine dynamics in the hippocampus of living mice to ask how neural activity, evoked by defined behavioral paradigms, influences synaptic stability. Finally we will test how synaptic activity defines neuronal spiking in CA1 place cells in vivo.
DFG Programme
Research Units
