Cognitive and motor networks as a basis of mobility in patients with Parkinson´s disease (C08)

• Subject Area: Clinical Neurology; Neurosurgery and Neuroradiology
• Term: from 2015 to 2023
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 178316478

The aim of this project is to advance multi-scale assessments of functional connectivity of cognitive and motor neuronal circuits to daily relevant tasks related to mobility in Parkinson´s disease patients, driving and walking. Intraoperative and postoperative recordings of neuronal network activities will be performed under realistic conditions, combining a driving simulator setup, virtual reality, mobile EEG, wearable movement-tracking sensors and eye-tracking techniques. Modulation of network activities will be performed by applying novel algorithms of deep brain stimulation such as patterned stimulation with evaluation of its impact on behavioral performance and assessment of reshaped subcortico-cortical network activity.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 936: Multi-Site Communication in the Brain
• Applicant Institution: Universität Hamburg
• Project Heads: Dr. Christian Karl Eberhard Moll, since 2/2019; Privatdozentin Dr. Monika Pötter-Nerger, since 2/2019