The role of Type I Secretion Systems (T1SS) in formation of the heterocyst specific cell wall (N) (A16*)

• Subject Area: Metabolism, Biochemistry and Genetics of Microorganisms
• Term: from 2015 to 2019
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 32152271

Heterocysts of filamentous cyanobacteria protect the oxygen labile nitrogenase by deposition of extra cell envelope layers composed of specific glycolipids. A type 1 secretion system (T1SS) is the exporter of the glycolipids and is composed of TolC and the ABC-transporter DevBCA. We want to identify homologous T1SS that are involved in heterocyst envelope formation by site directed mutagenesis, phenotype description and expression studies of the candidate proteins in time and space using fluorescent probes.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 766: The Bacterial Cell Envelope: Structure, Function and Infection Interface
• Applicant Institution: Eberhard Karls Universität Tübingen
• Project Head: Privatdozentin Dr. Iris Maldener