Dynamics of transcriptional complexes and interplay of the archaeal RNA polymerase with RNA processing proteins (A07)

• Subject Area: Biophysics
• Term: from 2015 to 2023
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 185476941

We plan to investigate the elongation phase of archaeal and eukaryotic transcription. We aim to i) delineate the structural (re-)organisation of the RNA polymerase I transcription machinery during the transition from the initiation to elongation phase at the single-molecule level and ii) to elucidate how transcription and co-transcriptional processes are orchestrated in Archaea with a special focus on the biochemical and structural characterisation of the coupling transcription and translation machinery and the role of Lsm-containing RNPs.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 960: Ribosome Formation: Principles of RNP Biogenesis and Control of their Function
• Applicant Institution: Universität Regensburg
• Project Head: Professorin Dr. Dina Grohmann