Dynamics of the Photoswitch-Process of Hemithioindigo and Hemiindigo (A12*)

• Subject Area: Biological and Biomimetic Chemistry ; Physical Chemistry of Molecules, Liquids and Interfaces, Biophysical Chemistry
• Term: from 2015 to 2019
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 27112786

Within the SFB 749 we aim to develop new HTI and HI based photoswitches with strongly redshifted absorption (>500 nm), while maintaining a high thermal stability of the metastable E isomeric state. The first studies of chiral HI derivatives will also be undertaken. In addition we plan to investigate the supramolecular binding of HTIs to DNA and how DNA hybridization can be photocontrolled. To this end, we will substituted the core structure of HTI with intercalation motives and DNA bases. In this context we will also study how the rigid environment of DNA influences the photoisomerization process.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 749: Dynamics and Intermediates of Molecular Transformations
• Applicant Institution: Ludwig-Maximilians-Universität München
• Project Head: Professor Dr. Henry Dube