Regulation of macrophage trafficking and function (A10)

• Subject Area: Immunology
• Term: from 2015 to 2023
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 165054336

Macrophages are important effector cells of the innate immune system and significantly contribute to the maintenance of tissue homeostasis. In this project, we aim to determine the metabolic wiring of different macrophage populations that develop at distinct stages of ontogeny and to define the role of immunometabolism for their trafficking and immune response. Therefore, we will combine macrophage fate mapping analysis with condition gene deletion in the mouse embryo and postnatal life in models of sterile inflammation and bacterial infection. We believe that these experiments will elucidate important pathways regulating macrophage functions in development and disease.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 914: Trafficking of Immune Cells in Inflammation, Development and Disease
• Applicant Institution: Ludwig-Maximilians-Universität München
• Project Head: Professor Dr. Christian Schulz