Amplification of NET formation and neutrophil aggregation for the resolution of inflammation (C03)

• Subject Area: Clinical Immunology and Allergology
• Term: from 2015 to 2023
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 261193037

Project C03 (Herrmann/Hoffmann) leverages on the finding that aggregated neutrophil extracellular traps (NETs) contribute to resolution of inflammation by their capacity to degrade cytokines and chemokines. Based on the preliminary data obtained during the first funding period C03 will characterize the glycosidase activity in NETs, which modulates immunoglobulin-function and, apart from cytokine/chemokine cleavage, is presumably responsible for the resolution of inflammation by NETs. Furthermore, a pharmacological approach will be developed that allows amplification of reactive oxygen species (ROS) production by neutrophils and, in consequence, the formation of aggregated NET that induce resolution of inflammation.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1181: Checkpoints for Resolution of Inflammation
• Applicant Institution: Friedrich-Alexander-Universität Erlangen-Nürnberg
• Project Heads: Professor Dr. Martin Herrmann; Professor Dr. Markus Hoffmann