Modification of cytokines by myeloperoxidase activity and (un)known mediators in resolution of psoriatic disease (A05)

• Subject Area: Clinical Immunology and Allergology
• Term: from 2015 to 2023
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 261193037

Project A05 investigates a novel immune regulatory role of myeloperoxidase (MPO) in neutrophils and monocytes/ macrophages. Preliminary data suggest that in the absence of MPO, the activity of proteases released from granulocytes and monocytes/macrophages is increased and activates the pro-inflammatory cytokine IL-36. Project A05 therefore addresses the functional role of MPO in resolution of inflammation, i.e. by modifying IL-36 cytokine activity.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1181: Checkpoints for Resolution of Inflammation
• Applicant Institution: Friedrich-Alexander-Universität Erlangen-Nürnberg
• Project Heads: Dr. Silke Frey, until 9/2022; Professorin Dr. Ulrike Hüffmeier; Dr. Ulrike Steffen