Glucocorticoid-mediated immune-metabolic reprogramming of macrophages during the resolution of inflammation (A03)

• Subject Area: Rheumatology
• Term: from 2015 to 2024
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 261193037

The preliminary data of project A03 indicates that glucocorticoid-mediated anti-inflammatory and pro-resolving effects rely on a reprogramming of mitochondrial metabolism and the production of the anti-inflammatory metabolite itaconate. We seek to better dissect the metabolic nexus of glucocorticoid receptor signaling and mitochondrial activity in macrophages. We will study the relevance of metabolic reprogramming for the anti-inflammatory and pro-resolving effects of glucocorticoids in vitro as well as in preclinical models of immune-mediated diseases and in patients.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1181: Checkpoints for Resolution of Inflammation
• Applicant Institution: Friedrich-Alexander-Universität Erlangen-Nürnberg
• Project Head: Professor Dr. Gerhard Krönke