A multi-centred, randomized, controlled trial comparing weight loss in endoscopically implanted duodenal-jejunal bypass liner vs intragastric balloons vs a sham procedure

• Applicant: Professor Dr. Albrecht Hoffmeister
• Subject Area: Gastroenterology ; General and Visceral Surgery
• Term: from 2016 to 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 276689665

• Final Report Year: 2022

Final Report Abstract

The WET trial proved through its excellent recruitment rate, high completeness of data and short-term results to be a well-designed and carried out trial. The loss of CE mark was unforeseeable and the efforts made to continue with the trial despite this setback were considerable. Despite the lack of power caused by the early trial stop, our data strongly suggest that IB and DJBL lead to comparable weight loss while implanted, which is superior to a sham procedure. However, these procedures fail to achieve effective weight loss 12 months after explantation. These results need to be interpreted with caution due to the trial’s early termination.

Publications

• Design of the Weight-loss Endoscopy Trial (WET): a multi-center, randomized, controlled trial comparing weight loss in endoscopically implanted duodenal-jejunal bypass liners vs. intragastric balloons vs. a sham procedure; BMC Gastroenterol 2018 Jul 18;18(1):118
  Marcus Hollenbach, Christiane Prettin, Felix Gundling, Wolfgang Schepp, Jochen Seufert, Jürgen Stein, Thomas Rösch, Jens Aberle, Jürgen Feisthammel, David Petroff, Albrecht Hoffmeister