Caveolin-1 and Filamin A: a novel mechanistic axis regulating B cell responses and immunopathology (B01)

• Subject Area: Immunology
• Term: since 2015
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 256073931

This project will continue the pioneering work linking defects in the nanoscale organization of the BCR to reduced BCR-mediated signal transduction, inefficient removal of cells expressing autoreactive BCRs and breaks in central tolerance. Briefly, B01 want to gain further insights into the mechanisms by which defective B cell activation leads to immunopathology. To this end, the molecular mechanism by which signals from the BCR are initiated will be study. Likewise, the role of the Cav1-FLNA axis in vivo will be investigated in the crosstalk between BCR and co-stimulatory signals provided by T cells.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1160: Immune-mediated pathology as a consequence of impaired immune reactions (IMPATH)
• Applicant Institution: Albert-Ludwigs-Universität Freiburg
• Project Head: Professorin Susana Minguet, Ph.D.