Targets and mediators of IL-17 in mouse models of psoriasis and skin infection (C01)

• Subject Area: Immunology ; Dermatology
• Term: from 2015 to 2023
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 246807620

The IL-17 response plays a major role in the defense against S. aureus but also in the pathogenesis of psoriasis. As we are interested in the specific mechanism of IL-17 induction and its downstream pathways we will (i) investigate how T cells expressing IL-17 are induced by S. aureus infections; (ii) analyze the keratinocyte gene expression response to IL-17 in different models of psoriasis as well as in S. aureus infection; (iii) investigate the role of the MALT1-NFκB pathway and the NIK non-canonical NFκB pathway in the keratinocyte response to IL-17A.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 156: The skin as sensor and effector orchestrating local and systemic immunity
• Applicant Institution: Ruprecht-Karls-Universität Heidelberg
• Project Heads: Florian Kurschus, Ph.D.; Professor Dr. Ari Waisman