Project Details
Projekt
GRK 639: The Molecular and Structural Basis of Tumorinstability
Subject Area
Basic Research in Biology and Medicine
Term
from 2000 to 2006
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 273153
We investigate the progressive genomic destabilization of the genome, which is the hallmark of malignant tumors. Our approach comprises established genetic instability syndromes, such as microsatelite and chromosomal instability, but also structural aberrations of genes, chromosome domains, structural nucleoproteins, and chromatin organizers. For this enlargened definition we have coined the term "tumorinstability". In our eyes "tumorinstability" is a multifactorial process that progresses in a pleyotropic fashion and leads to global disorder of the spatial organization of the entire cell nucleus. The scientific groups constituting our research training group are interested in various factors and mechanisms of tumorinstability and contribute diverse experimental approaches. By a concerted action we are aiming at the composition of an integrated picture of the entire process, which combines aspects of basic sciences, animal models, and clinical oncology. Our efforts are grouped into three main areas of reasearch, which are interlinked by bridging projects and shared methodology.
DFG Programme
Research Training Groups
Applicant Institution
Julius-Maximilians-Universität Würzburg
Participating Researchers
Professor Dr. Ricardo Benavente; Dr. Sergei Chuvpilo; Professor Dr. Christoph Englert; Dr. Joachim Fensterle; Dr. Axel Greiner; Privatdozent Dr. Rudolf Götz; Privatdozent Dr. Robert Hock; Professor Dr. Jörg Kalla; Dr. Burkhard Kneitz; Professor Dr. German Ott; Privatdozent Dr. Alois Palmetshofer; Professor Dr. Ulf Rüdiger Rapp; Professor Manfred Schartl, Ph.D.; Professor Dr. Ulrich Scheer; Professor Dr. Michael Schmid; Professor Dr. Peter Seibel; Professor Dr. Edgar Serfling; Professorin Dr. Helga Stopper; Dr. Andreas Zettl
