Bioorthogonal Nanodiamond / Glycopolymer Hybrid Design to Simulate the Structure of Viruses

• Applicants: Professor Dr. Christopher Barner-Kowollik; Anja Goldmann, Ph.D.
• Subject Area: Polymer Materials ; Synthesis and Properties of Functional Materials
• Term: from 2015 to 2018
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 271285424

• Final Report Year: 2018

Final Report Abstract

The current project has unambiguously shown that several attractive avenues exist – from photochemical to adsorption processes – to graft synthetic polymers including bioactive glycopolymers in a highly efficient and controlled fashion onto nanodiamonds. The project has inspired the applicants to continue working in the area of virus-inspired surface design. Dr. Andrea Lauer commenced working on an alternative co-grafting strategy exploiting λ-orthogonal photochemistry for functional nanodiamond design, which will be continued and finalized in our laboratories by Dr. Rhiannon Batechlor.

Publications

• Fructose-Coated Nanodiamonds: Promising Platforms for Treatment of Human Breast Cancer. Biomacromolecules 2016, 17, 2946–2955
  Zhao, J.; Lai, H.; Lu, H.; Barner-Kowollik, C.; Stenzel, M.H. Xiao P.
  (See online at https://doi.org/10.1021/acs.biomac.6b00754)
• Light-Triggered Chemistries for Macromolecular Precision Design. 25th Lecture Conference in Photochemistry, Jena, Germany, September 2016 [Award for the best Poster Presentation]
  A. S. Goldmann, C. Barner-Kowollik
  
• Polymer Functional Nanodiamonds by Light-Induced Ligation. Macromolecules 2016, 49 (5), 1712–1721
  Wuest, K. N. R.; Trouillet, V.; Goldmann, A. S.; Stenzel, M. H.; Barner-Kowollik, C.
  (See online at https://doi.org/10.1021/acs.macromol.5b02607)
• Direct Light-induced (Co-)Grafting of Photoactive Polymers to Graphitic Nanodiamonds. Polym. Chem. 2017, 8, 838-842
  Wuest, K. N. R.; Trouillet, V.; Köppe, R.; Roesky, P. W.; Goldmann, A. S.; Stenzel, M. H.; Barner-Kowollik, C.
  (See online at https://doi.org/10.1039/c6py02035f)
• Fluorescent Glyco Single-Chain Nanoparticle Decorated Nanodiamonds. ACS Macro Letters 2017, 6, 1168-1174
  Wuest, K. N. R.; Lu, H.; Thomas, D. S.; Goldmann, A. S.; Stenzel, M. H.; Barner- Kowollik, C.
  (See online at https://doi.org/10.1021/acsmacrolett.7b00659)
• Light-induced Grafting of Functional Polymers to Nanodiamonds. 14th Annual UNESCO/IUPAC Workshop and Conference on Macromolecules and Materials, April 2017, Stellenbosch, South Africa
  Wuest, K. N. R.; Trouillet, V.; Köppe, R.; Roesky, P. W.; Goldmann, A. S.; Stenzel, M. H.; Barner-Kowollik, C.
  
• Polymer Functional Nanodiamonds by Light-Induced Reactions. APME Advanced Polymers, Macromolecular Engineering, Ghent, Belgium, May 2017
  A.S. Goldmann, K.N.R. Wuest, V. Trouillet, M. H. Stenzel, C. Barner-Kowollik
  
• Delivery of Amonafide from Fructose-Coated Nanodiamonds by Oxime Ligation for Treatment of Human Breast Cancer. Biomacromolecules 2018, 17, 2946-2955
  Zhao, J.; Lu, M.; Lai, H.; Lu, H.; Lalevée, J.; Barner-Kowollik, C.; Stenzel, M. H.; Xiao, P.
  (See online at https://doi.org/10.1021/acs.biomac.7b01592)