Controlled release of volatile mosquito repellents from nanostructured polymers to reduce infectious tropical diseases: Part II: Bicomponent fibers as drug-release device

• Antragsteller: Professor Dr.-Ing. René Androsch; Dr. Andreas Leuteritz
• Fachliche Zuordnung: Biologische und Biomimetische Chemie
• Förderung: Förderung von 2015 bis 2021
• Projektkennung: Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 270456781

• Erstellungsjahr: 2021

Zusammenfassung der Projektergebnisse

Main goal of the project was contributing to the further reduction of tropical infectious diseases in Africa. To reach this goal, specific tasks were defined, which included (a) building educational and research capacities in Mozambique, and (b) development of new tools for mosquito-bite related disease control under outdoor situations. Solving both tasks required intense collaborations between partners in Germany, South Africa, and Mozambique. As a result of the collaborations, it was achieved that at the University of Maputo facilities for physico-chemical testing of mosquito repellents, for testing the effectiveness of repellents using a sophisticated wind-tunnel device with an incorporated mosquito-tracking system, and for supply of mosquitoes for wind-tunnel tests were developed. Students and staff members of the University of Maputo were trained in operating these facilities as well as for field trials and community sociological surveys. Regarding the development of novel devices providing long-term protection for mosquitoes bites at outdoor conditions the concept of storing and slow-release of classical repellents in polymer matrices was followed, with the collaboration among the partners yielding insights into both fundamentals of polymer/repellent interactions and engineering of specific tools like repellent-containing sandals, with the latter also considering the design-needs of the local population in rural areas of Mozambique. The collaboration between institutions in Germany, in Mozambique, and in South Africa, finally, led to the development of a lasting research-network, with further student/staffexchange activities and joint research projects expected.

Projektbezogene Publikationen (Auswahl)

• Phase behavior of the polymer/drug system PLA/DEET. Polymer 126, 116–125 (2017)
  Sungkapreecha C, Iqbal N, Gohn AM, Focke WW, Androsch R
  
• Phase behavior of the polymer/drug system PLA/DEET: Effect of PLA molar mass on subambient liquid-liquid phase separation. Thermochim Acta 660, 77–81 (2018)
  Sungkapreecha C, Beily MJ, Kressler J, Focke WW, Androsch R
  
• Biodegradable Electrospun PLLA Fibers Containing the Mosquito-Repellent DEET. Eur Polym J 113, 377-384 (2019)
  Bonadies I, Longo A, Androsch R, Jehnichen D, Göbel M, Di Lorenzo ML
  
• Crystallization of poly (L-lactic acid) (PLLA) in solution with the mosquito-repellent N,N-diethyl-3-methylbenzamide (DEET). Polym Cry 2:e10029 (2019)
  Sungkapreecha C, Iqbal N, Focke WW, Androsch R
  
• Microporous polyolefin strands as controlled-release devices for mosquito repellents. Chem Eng J 360, 435–444 (2019)
  Mapossa AB, Sibanda MM, Sitoe A, Focke WW, Braack L, Ndonyane C, Mouatcho J, Smart J, Muaimbo H, Androsch R, Loots MT
  
• Competition between liquid-liquid de-mixing, crystallization, and glass transition in solutions of PLA of different stereochemistry and DEET. Chin J Polym Sci 38, 174–178 (2020)
  Sungkapreecha C, Focke WW, Androsch R
  
• Development, characterization and modeling of mosquito repellent release from microporous devices. SPE Polymers 1, 90–100 (2020)
  Sitoe A, Mapossa AB, Focke WW, Muiambo H, Androsch R, Wesley-Smith J
  
• Mosquito repellent thermal stability, permeability and air volatility. Pest Management Sci 76, 1112–1120 (2020)
  Mapossa AB, Sitoe A, Focke WW, Homa I, du Toit EL, Androsch R, Sungkapreecha C, van der Merwe EM
  
• Melt-Spun Poly(D,L-lactic acid) Monofilaments containing N,N-Diethyl-3-Methylbenzamide as Mosquito Repellent. Materials 14, 638 (2021)
  Ferreira I, Brünig H, Focke W, Boldt R, Androsch R, Leuteritz A
  
• Mosquito-repellent controlled-release devices for fighting infectious diseases: A review. Malaria J. 20, 165 (2021)
  Mapossa AB, Focke WW, Tewo RK, Androsch R, Kruger T
  
• Phase behavior of solvent-rich compositions of the polymer/drug system poly (butylene succinate) and N,N-diethyl-3-methylbenzamide (DEET). Coll Polym Sci 299, 873–881 (2021)
  Yener HE, Hillrichs G, Androsch R