Control of DNA translocation through solid-state nanopores with integrated electrodes

• Applicants: Professor Dr. Peter Reimann; Professor Dr. Günter Reiss
• Subject Area: Statistical Physics, Nonlinear Dynamics, Complex Systems, Soft and Fluid Matter, Biological Physics
• Term: from 2015 to 2018
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 269849114

We address the translocation of short DNA fragments (or nanoparticles etc.) through an artificial nanopore in a thin solid-state membrane under the influence of an externally applied electrical field. The general objective in this context is to draw conclusions from the observable current signals in response to the applied voltage with respect to the detailed structural and dynamical properties of the translocating DNA, ideally up to the sequence of the base pairs. Our specific goal is to explore new concepts of controlling and detecting DNA translocation by means of one or several electrodes which are integrated directly into the membrane. The main focus will be on modeling and optimization of the electrokinetic and hydrodynamic forces acting upon the DNA and of the electric currents through the various electrodes. Several quantitatively unknown model parameters will be determined by means of a basic experiment.

• DFG Programme: Research Grants