The Reelin-GPVI axis in acute myocardial infarction beyond thrombosis (A05)

• Subject Area: Cardiology, Angiology
• Term: from 2015 to 2023
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 236177352

TP A05 aims to understand the impact of platelets in inflammation, cell survival and scar formation and the role of the glycoprotein VI (GPVI)-Reelin axis in these processes post AMI. We will investigate non hemostatic/thrombotic functions of platelets with respect to platelet-mediated inflammation and platelet-induced cardiomyocyte survival and fibroblast activation post AMI. The role of Reelin in GPVI mediated platelet activation and the impact of Reelin post AMI will be determined using an antibody that blocks Reelin oligomerisation and Reelin mutant mice.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1116: Master switches in cardiac ischemia
• Applicant Institution: Heinrich-Heine-Universität Düsseldorf
• Project Head: Professorin Dr. Margitta Elvers