Ventricular arrhythmogenesis by ion channel remodeling after acute myocardial infarction (AMI) (A01)

• Subject Area: Anatomy and Physiology
• Term: from 2015 to 2022
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 236177352

Ventricular arrhythmias are cause and prognostic marker of increased mortality early after AMI. Using an unbiased experimental approach (next generation sequencing) combined with optical mapping and mathematical modeling, loco-regional changes in expression and function of ionic conductances will be analyzed, which result in electrical instability of the injured myocardium. They will be target for exploring the therapeutic potential of innovative photopharmacological strategies for spatiotemporal modulation of ion channels.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1116: Master switches in cardiac ischemia
• Major Instrumentation: Optical imaging set up: camera system, optical hardware, LED, filters
• Instrumentation Group: 5990 Sonstige optische Bauelemente
• Applicant Institution: Heinrich-Heine-Universität Düsseldorf
• Project Head: Professor Dr. Nikolaj Klöcker