"Closing the cycle": Sub-modules in synaptic vesicle membrane targeting, fusion and endocytosis (C09*)

• Subject Area: Molecular Biology and Physiology of Neurons and Glial Cells
• Term: from 2015 to 2018
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 25065445

For synaptic transmission, a sequence of interconnected functional modules obviously organizes synaptic vesicle exo- and endocytosis. Using highly accessible Drosophila neuromuscular synapses, we seek to investigate these coupling processes in the intact living animal. Central to the project is a flash-freeze approach which allows for rapidly capturing ultrastructure after light induced stimulation. We thus hope to contribute to a deeper understanding of how functional sub-modules are coupled for efficient neurotransmission

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 740: From Molecules to Modules: Organisation and Dynamics of Functional Units in Cells
• Applicant Institution: shared FU Berlin and HU Berlin through:; Charité - Universitätsmedizin Berlin
• Co-Applicant Institution: Freie Universität Berlin
• Project Head: Professor Dr. Stephan J. Sigrist