Identification and characterization of a novel metazoan disaggregase module (B08*)

• Subject Area: Biochemistry
• Term: from 2015 to 2018
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 25065445

Protein disaggregation provides an alternative pathway for clearance of protein aggregates. We have recently identified the components of this disaggregation module as Hsp110, Hsp70 and Hsp40. With this project we aim to fully characterize this tripartite disaggregase module using the metazoan model system C. elegans as well as human cells to gain insight into the regulation, activity and substrate spectrum of this disaggregase module in the context of the cellular proteostasis network.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 740: From Molecules to Modules: Organisation and Dynamics of Functional Units in Cells
• Applicant Institution: shared FU Berlin and HU Berlin through:; Charité - Universitätsmedizin Berlin
• Co-Applicant Institution: Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP); im Forschungsverbund Berlin e.V.
• Project Head: Dr. Janine Kirstein-Miles