Cell-type-specific modulation of NF-ĸB in traumatic brain injury (A03)

• Subject Area: Molecular Biology and Physiology of Neurons and Glial Cells ; Molecular and Cellular Neurology and Neuropathology ; Orthopaedics, Traumatology, Reconstructive Surgery
• Term: since 2015
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 251293561

This project demonstrated that overall gene expression changes after closed head TBI strongly depend on post-traumatic hematoma formation. Our data also show that IKK/NF-B signaling in glia cells is a critical player in the orchestration of the post-traumatic neuroimmune response and how astrocytic NF-B may interfere with blood-brain barrier homeostasis. On the basis of these findings we aim to further characterize the role of NF-B in the bi-directional brain-immune communication after TBI. Because prolonged IKK/NF-B signaling in oligodendrocytes disturbed myelin maintenance, we also intend to identify NF-B regulated effectors triggering TBI-induced white matter loss.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1149: Danger Response, Disturbance Factors and Regenerative Potential after Acute Trauma
• Applicant Institution: Universität Ulm
• Project Head: Professor Dr. Thomas Wirth