Effect of timing of umbilical cord clamping on cerebral tissue oxygen saturation in term and preterm infants
Gynaecology and Obstetrics
Final Report Abstract
The randomized controlled trial in which Dr Lorenz planned to look at the effect of timing of cord clamping on postnatal reference ranges of heart rate, oxygen saturation and cerebral oxygenation unfortunately did not take place. Several reasons contributed to the fact that the study could not be conducted as it was planned which were out of Dr Lorenz’s control. However, during her research fellowship from the DFG Dr Lorenz designed two new clinical studies that looked at cerebral oxygenation during skin-to-skin care. The results showing the safety of skin-to-skin care in very preterm infants had a remarkable impact on the local media in Australia such as TV news and radio broadcasts. Moreover, the results of her research study already changed clinical practice at the Royal Women’s Hospital in Melbourne and skin-to-skin care is now offered earlier after birth and also in more immature preterm infants. It might also lead to a change in clinical practice in other neonatal intensive care units all over the world. Moreover, Dr Lorenz showed a great interest in clinical studies in the delivery room. She has additionally performed a manikin study testing a new facemask to improve neonatal resuscitation. Subsequently, she has designed and performed a clinical trial comparing this new facemask with the current gold standard mask in term infants that need mask ventilation during transition in the delivery room. At the time of this final report the last patients have already been recruited and data will be analysed shortly. Given her increasing interest in neonatal resuscitation Dr Lorenz also performed a retrospective analysis of video recordings looking at the effect of stimulation on initiation of breathing in the delivery room and helped in conducting an observational study describing the initiation of breathing in healthy infants immediately after birth using lung ultrasound. In summary, Dr Lorenz successfully initiated, performed and has already published several clinical trials as well as retrospective analyses and manikin studies during her research fellowship at the Royal Women’s Hospital in Melbourne, although the initially planned clinical study could unfortunately not be performed.
Publications
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(2018) Cerebral oxygenation during skin-to-skin care in preterm infants not receiving respiratory support. Archives of disease in childhood. Fetal and neonatal edition 103 (2) F137-F142
Lorenz, Laila; Marulli, Adriana; Dawson, Jennifer A.; Owen, Louise S.; Manley, Brett J.; Donath, Susan M.; Davis, Peter G.; Kamlin, C. Omar F.
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A new suction mask to reduce leak during neonatal resuscitation: a manikin study. Arch Dis Child Fetal Neonatal Ed. 2016 Sep
Lorenz L, Maxfield DA, Dawson JA, Kamlin CO, McGrory L, Thio M, Donath SM, Davis PG
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Lung ultrasound during the initiation of breathing in healthy term and late preterm infants immediately after birth, a prospective, observational study. Resuscitation. 2017 May
Blank DA, Rogerson SR, Kamlin CO, Fox LM, Lorenz L, Kane SC, Polglase GR, Hooper SB, Davis PG
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Lung ultrasound immediately after birth to describe normal neonatal transition: an observational study. Arch Dis Child Fetal Neonatal Ed. 2017 Jun
Blank DA, Kamlin COF, Rogerson SR, Fox LM, Lorenz L, Kane SC, Polglase GR, Hooper SB, Davis PG
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Physical stimulation of newborn infants in the delivery room. Arch Dis Child Fetal Neonatal Ed. 2017 Jun
Gaertner VD, Flemmer SA, Lorenz L, Davis PG, Kamlin COF
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Skin-to-skin care in preterm infants receiving respiratory support does not lead to physiological instability. Arch Dis Child Fetal Neonatal Ed. 2017 Jan
Lorenz L, Dawson JA, Jones H, Jacobs ES, Cheong JL, Donath SM, Davis PG, Kamlin CO
