Interaction of adhesion GPCR signalling and ionotropic pathways during mechano-sensory signal transduction

• Applicants: Professor Dr. Robert J. Kittel; Professor Dr. Tobias Langenhan
• Subject Area: Anatomy and Physiology ; Pharmacology
• Term: from 2014 to 2022
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 246212759

Building upon our observation that the adhesion G protein-coupledreceptor (aGPCR) dCIRL acts as a metabotropic mechanosensor inDrosophila, this project will carry out a detailed investigation of thefunctional interaction between dCIRL and ionotropicmechanotransduction channels of the TRP (transient receptorpotential) family. In order to judge the generality of such an interplay,we will focus on two mechanosensory systems: (i) the larvalchordotonal organ, which detects external mechanical stimuli and (ii)specialized central neurons of adult Drosophila, which monitor internalosmolality.

• DFG Programme: Research Units
• Subproject of: FOR 2149: Elucidation of Adhesion-GPCR Signalling