The molecular basis of maintaining genome integrity in the mammalian germline during meiosis

• Applicant: Professor Dr. Attila Tóth
• Subject Area: Cell Biology ; General Genetics and Functional Genome Biology ; Biochemistry
• Term: from 2014 to 2017
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 263545090

• Final Report Year: 2021

Final Report Abstract

No abstract available

Publications

• Alignment of homologous chromosomes and effective repair of programmed DNA double-strand breaks during mouse meiosis require the minichromosome maintenance domain containing 2 (MCMDC2) protein. PLoS Genetics, Vol. 12. 2016, Issue 10, e1006393.
  Finsterbusch F., Ravindranathan R., Dereli I., Stanzione M., Tränkner D., Tóth A.
  (See online at https://doi.org/10.1371/journal.pgen.1006393)
• Meiotic DNA break formation requires the unsynapsed chromosome axis-binding protein IHO1 (CCDC36) in mice. Nature Cell Biology, Vol. 18. 2016, pp. 1208–1220.
  Stanzione M., Baumann M., Papanikos F., Dereli I., Lange J., Ramlal A., Tränkner D., Shibuya H., de Massy B., Watanabe Y., Jasin M., Keeney S., Tóth A.
  (See online at https://doi.org/10.1038/ncb3417)
• The enigmatic meiotic dense body and its newly discovered component, SCML1, are dispensable for fertility and gametogenesis in mice. Chromosoma, Vol. 126. 2017, Issue 3, pp. 399-415.
  Papanikos F., Daniel K., Goercharn-Ramlal A., Fei J.F., Kurth T., Wojtasz L., Dereli I., Fu J., Penninger J., Habermann B., Surani A., Stewart A.F., Tóth A.
  (See online at https://doi.org/10.1007/s00412-016-0598-1)
• Mouse ANKRD31 Regulates Spatiotemporal Patterning of Meiotic Recombination Initiation and Ensures Recombination between X and Y Sex Chromosomes. Molecular Cell, Vol. 74. 2019, Issue 5, pp. 1069-1085.e11.
  Papanikos F., Clément J.A.J., Testa E., Ravindranathan R,. Grey C., Dereli I., Bondarieva A., Valerio-Cabrera S., Stanzione M., Schleiffer A., Jansa P., Lustyk D., Fei J.F., Adams I.R., Forejt J., Barchi M., de Massy B., Tóth A.
  (See online at https://doi.org/10.1016/j.molcel.2019.03.022)
• Proline-rich protein PRR19 functions with cyclin-like CNTD1 to promote meiotic crossing over in mouse. Nature Communications, Vol. 11. 2020, Article number: 3101.
  Bondarieva A., Raveendran K., Telychko V., Rao P.H.B.D., Ravindranathan R., Zorzompokou C., Finsterbusch F., Dereli I., Papanikos F., Tränkner D., Schleiffer A., Fei J.F., Klimova A., Ito M., Dhananjaya S., Kulkarni D.S., Roeder I., Hunter N., Tóth A.
  (See online at https://doi.org/10.1038/s41467-020-16885-3)
• Four-pronged negative feedback of DSB machinery in meiotic DNA-break control in mice. Nucleic Acids Research, Vol. 49. 2021, Issue 5, pp. 2609–2628.
  Dereli I., Stanzione M., Olmeda F., Papanikos F., Baumann M., Demir S, Carofiglio F., Lange J., de Massy B., Baarends W.M., Turner J., Rulands S., Tóth A.
  (See online at https://doi.org/10.1093/nar/gkab082)