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Assessment of cerebral metabolic and microstructural alterations in aging human brain and in patients by using an innovative whole brain 1H magnetic resonance spectroscopic technique in combination with quantitative magnetic resonance imaging

Subject Area Clinical Neurology; Neurosurgery and Neuroradiology
Human Cognitive and Systems Neuroscience
Term from 2014 to 2022
Project identifier Deutsche Forschungsgemeinschaft (DFG) - Project number 263370457
 
Final Report Year 2022

Final Report Abstract

With is project we have successfully studied healthy aging human brain as well as patients with neurodegenerative or mental orders by use of an innovative whole brain 1H magnetic resonance spectroscopic technique, which enables simultaneously determination of brain metabolites over multiple large or small specific brain structures, in combination with quantitative magnetic resonance imaging that could be used to determine brain tissue relaxation, curtail thickness, and subcortical gray matter volumes. Our studies on healthy volunteers demonstrated that, normal aging has influences on brain metabolism, brain microstructures, and neuronal volume of healthy human brain, with associated measurable changes in brain metabolite concentrations, tissue relaxation times, cortical thickness and subcortical gray matter volumes. These measurable parameters, determined either global over the whole brain or over each brain lobe and cerebellum, as well as in multiple specific small brain regions, could be used as useful biomarkers to quantify aging effects on healthy human brain. Moreover, our studies on patients with neurodegenerative or mental disorders showed that, these measurable parameters could also be used as useful biomarkers to sensitively detect neurodegenerative or mental diseaserelated brain pathological alterations in patients, with the derived values from our studies on healthy subjects (healthy data-collection) being used as reference data. Encouraged by success of this project and based on the obtained results, we have proposed a following project with the title “Investigation of brain metabolic changes in Patients with Parkinson disease and with Major Depressive Disorder with whole brain magnetic resonance spectroscopic imaging and creation of basic construction for brain metabolic radiomics”, by aiming to improve the early recognition and diagnosis of neurodegenerative diseases and mental disorders.

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