Die Regulation des Ceramid/Sphingosin-1-Phosphat-Gleichgewichts durch Ceramidasen und Sphingosinkinasen in Nierenzellen und deren Bedeutung für Entzündungs- und Firbroseprozesse

• Applicant: Professor Dr. Josef M. Pfeilschifter
• Co-Applicant: Professorin Dr. Andrea Huwiler (†)
• Subject Area: Pharmacology
• Term: from 2006 to 2014
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 26333961

Final Report Abstract

No abstract available

Publications

• (2008) Mesangial cells derived from sphingosine kinase 1 and 2 deficient mice display opposite behaviour to apoptotic stimuli. Biol Chem, 389: 1399-1407
  Hofmann LP, Ren S, Schwalm S, Pfeilschifter J, Huwiler A
  (See online at https://doi.org/10.1515/hsz-2014-0289)
• (2008) Sphingolipids take the center stage: Sphingosine 1-phosphate and its receptors as new drug targets, Biochem Pharmacol 75: 1893-1900
  Huwiler A, Pfeilschifter J
  (See online at https://doi.org/10.1016/j.bcp.2007.12.018)
• (2008) Sphingosine kinase-1 is a hypoxia-regulated gene that stimulates migration of human endothelial cells. Biochim Biophys Res Commun 368: 1020-1025
  Schwalm S, Döll F, Römer I, Bubnova S, Pfeilschifter J, Huwiler A
  (See online at https://doi.org/10.1016/j.bbrc.2008.01.132)
• (2009) Involvement of the ABC-transporter ABCC1 and the sphingosine-1-phosphate receptor subtype S1P3 in the cytoprotection of human fibroblasts by the glucocorticoid dexamethasone. J Mol Med 87: 645-657
  Nieuwenhuis B, Lüth A, Huwiler A, Chun J, Pfeilschifter J, Schäfer-Korting M, Kleuser B
  (See online at https://doi.org/10.1007/s00109-009-0468-x)
• (2009) The immunomodulatory sphingosine 1-phosphate analog FTY720 reduces lesion size and improves neurological outcome in a mouse model of cerebral ischemia. Biochem Biophys Res Commun, 389: 251-256
  Czech B, Pfeilschifter W, Omrani NM, Strobel MA, Kahles T, Neumann-Haefelin T, Rami A, Huwiler A, Pfeilschifter J
  (See online at https://doi.org/10.1016/j.bbrc.2009.08.142)
• Transforming growth factor-β2 upregulates sphingosine kinase-1 activity, which in turn attenuates the fibrotic response to TGF-β2 by impeding CTGF expression. Kidney Int 76: 857-867
  Ren S, Babelova A, Moreth K, Xin C, Eberhardt W, Doller A, Pavenstädt H, Schaefer L, Pfeilschifter J Huwiler A
  (See online at https://doi.org/10.1038/ki.2009.297)
• (2010) A novel mode of action of the putative sphingosine kinase inhibitor 2-(p-hydroxyanilino)-4-(p-chlorophenyl) thiazole (SKI II): induction of lysosomal sphingosine kinase 1 degradation. Cell Physiol Biochem, 26: 97-104
  Ren S, Xin C, Pfeilschifter J, Huwiler A
  (See online at https://doi.org/10.1159/000315110)
• (2010) Glucocorticoids protect renal mesangial cells from apoptosis by increasing cellular sphingosine-1-phosphate levels. Kidney Int 77: 870-879
  Förster A, Emmler T, Schwalm S, Ebadi M, Meyer zu Heringdorf D, Nieuwenhuis B, Kleuser B, Huwiler A, Pfeilschifter J
  (See online at https://doi.org/10.1038/ki.2010.62)
• (2010) Nitric oxide upregulates sphingosine kinase-1 expression and activity in the human endothelial cell line EA.hy 926 and critically regulates endothelial tube formation. Br J Pharmacol 160: 1641-1651
  Schwalm S, Pfeilschifter J, Huwiler A
  (See online at https://doi.org/10.1111/j.1476-5381.2010.00818.x)
• 20100311843A1: Compositions and methods for the treatment of glomerulonephritis
  B. Johansen, A. Huwiler
  
• (2011) A prokaryotic S1P lyase degrades extracellular S1P in vitro and in vivo: implication for treating hyperproliferative disorders. PLOS One, 6: e22436
  Huwiler A, Bourquin F, Kotelevets N, Pastukhov O, Capitani G, Grütter MG, Zangemeister-Wittke U
  (See online at https://doi.org/10.1371/journal.pone.0022436)
• (2011) Activation of sphingosine kinase 2 is an endogenous protective mechanism in cerebral ischemia. Biochem Biophys Res Commun. 413: 212-217
  Pfeilschifter W, Czech-Zechmeister B, Sujak M, Mirceska A, Koch A, Rami A, Steinmetz H, Foerch C, Huwiler A, Pfeilschifter J
  (See online at https://doi.org/10.1016/j.bbrc.2011.08.070)
• EP2505589 A1: Novel sphingolipid heterocyclic compounds as modulators of sphingolipid signaling and uses thereof
  Stark, H., Zivkovic, A., Pfeilschifter, J., and Huwiler, A
  
• PCT/EP2011/071446: Use of prokaryotic sphingosine-1-phosphate lyases and of sphingosine-1-phosphate lyases lacking a transmembrane domain for treating hyperproliferative and other diseases
  Zangemeister-Wittke U., Huwiler, A., Bourquin, F., and Grütter, M
  
• (2013) Dual role of sphingosine kinase 1 in promoting the differentiation of dermal fibroblasts and the dissemination of melanoma cells. Oncogene
  Albinet V, Bats M-L, Huwiler A, Rochaix P, Chevreau C, Segui B, Levade T, Andrieu-Abadie N
  (See online at https://doi.org/10.1038/onc.2013.303)
• (2013) Sphingosine-1-phosphate: a Janus-faced mediator of fibrotic diseases. Biochim Biophys Acta - Mol Cell Biol Lipids 1831: 239-250
  Schwalm S, Pfeilschifter J, Huwiler A
  (See online at https://doi.org/10.1016/j.bbalip.2012.07.022)
• (2013) Targeting the sphingosine kinase/ sphingosine 1-phosphate pathway to treat chronic inflammatory kidney diseases. Basic and Clinical Pharmacology and Toxicology
  Schwalm S, Pfeilschifter J, Huwiler A
  (See online at https://doi.org/10.1111/bcpt.12103)