Project Details
Projekt
Mechanisms of niche – stem cell unit origin and maintenance (A11)
Subject Area
Cell Biology
Term
from 2014 to 2022
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 122491522
The stem cell niche is key to maintain stemness in every stem cell population reported in plants and animals. Despite the essential function of stem cell - niche interaction in stem cell biology, little is known about how somatic stem cells and niche get together during organ formation. In the previous funding period, we used neuromasts, sensory organs of the lateral line system in fish, as a minimal model to explore niche-stem cell interaction during organogenesis. We will now exploit this system to address niche formation at the molecular level by combining our expertise in 4D imaging and lineage analysis with the acquisition of new RNAseq data, to identify molecular determinants critical for niche induction and maintenance during homeostasis and perturbed conditions.
DFG Programme
Collaborative Research Centres
Applicant Institution
Ruprecht-Karls-Universität Heidelberg
Project Head
Professor Lazaro Centanin, Ph.D.
