Platelet migration in atherosclerosis progression and plaque instability (B06)

• Subject Area: Cardiology, Angiology
• Term: since 2014
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 238187445

Migration has emerged as a novel effector function of platelets in acute inflammation. The contribution of this novel effector function of immune-responsive platelets to chronic (vascular) inflammation is not understood. Our project aims to reveal molecular mechanisms of migrating platelets recruited to atherosclerotic plaques and to unveil potential platelet-centered therapeutic strategies that have the potential to limit atherosclerosis progression.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1123: Atherosclerosis: Mechanisms and Networks of Novel Therapeutic Targets
• Applicant Institution: Ludwig-Maximilians-Universität München
• Project Heads: Professor Dr. Bernd Engelmann, until 6/2022; Professor Dr. Steffen Massberg; Dr. Leo Nicolai